id: gomodel:663d668500002178
title: "phosphatidylinositol/phosphatidylinositol phosphate/ biosynthetic process\
  \ (GO:0043647)\t (GO:0006661)\n"
taxon: NCBITaxon:4896
status: production
date_modified: '2025-05-14'
comments:
- Need to add "inositol phosphate metabolic process" (GO:0043647) to everything after
  plc1
- add major intermediates
- reference https://www.pombase.org/reference/PMID:38133430
activities:
- id: gomodel:663d668500002178/663d668500002532
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN007434641
      - RGD:61993
      - WB:WBGene00004036
      - dictyBase:DDB_G0292736
      - TAIR:locus:2075696
      - RGD:69424
      - UniProtKB:Q00722
      - MGI:MGI:2150308
      - RGD:3347
      - UniProtKB:P10894
      - UniProtKB:Q9P212
      - RGD:3344
      - MGI:MGI:97615
      - UniProtKB:Q01970
      - RGD:3346
      - RGD:621004
      - MGI:MGI:97613
      - UniProtKB:O75038
      - UniProtKB:Q86YW0
      - UniProtKB:Q9NQ66
      - UniProtKB:P19174
      - RGD:3348
      - UniProtKB:P16885
      - UniProtKB:P51178
      - RGD:621025
      - SGD:S000006189
      - MGI:MGI:97616
      - FB:FBgn0262738
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC22F8.11
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004435
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000006189
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    term: GO:0032958
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN007434641
      - RGD:61993
      - WB:WBGene00004036
      - dictyBase:DDB_G0292736
      - TAIR:locus:2075696
      - RGD:69424
      - UniProtKB:Q00722
      - MGI:MGI:2150308
      - RGD:3347
      - UniProtKB:P10894
      - UniProtKB:Q9P212
      - RGD:3344
      - MGI:MGI:97615
      - UniProtKB:Q01970
      - RGD:3346
      - RGD:621004
      - MGI:MGI:97613
      - UniProtKB:O75038
      - UniProtKB:Q86YW0
      - UniProtKB:Q9NQ66
      - UniProtKB:P19174
      - RGD:3348
      - UniProtKB:P16885
      - UniProtKB:P51178
      - RGD:621025
      - SGD:S000006189
      - MGI:MGI:97616
      - FB:FBgn0262738
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002565
- id: gomodel:663d668500002178/663d668500002294
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004825
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC794.08
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0043495
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005886
  part_of:
    type: BiologicalProcessAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0046854
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004825
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004825
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004825
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002629
    downstream_activity: gomodel:663d668500002178/663d668500002205
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002629
    downstream_activity: gomodel:663d668500002178/663d668500002205
- id: gomodel:663d668500002178/663d668500002179
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9560432
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000316
      reference: PMID:9560432
      with_objects:
      - PomBase:SPAC4F8.15
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000628316
      - PomBase:SPAC20G8.03
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC20G8.03
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0005366
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000002905
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005886
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9560432
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000628316
      - PomBase:SPAC4F8.15
      - PomBase:SPAC20G8.03
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: GO:1904679
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-14'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/67c10cc400004789
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9560432
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000316
      reference: PMID:9560432
      with_objects:
      - PomBase:SPAC4F8.15
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000628316
      - PomBase:SPAC20G8.03
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-26'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/67b1629100003514
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9560432
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000316
      reference: PMID:9560432
      with_objects:
      - PomBase:SPAC4F8.15
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000628316
      - PomBase:SPAC20G8.03
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-26'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/67b1629100003514
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9560432
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000316
      reference: PMID:9560432
      with_objects:
      - PomBase:SPAC4F8.15
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000628316
      - PomBase:SPAC20G8.03
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000316
      reference: PMID:9560432
      with_objects:
      - PomBase:SPAC4F8.15
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002281
  - type: CausalAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:9560432
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000628316
      - PomBase:SPAC20G8.03
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002281
- id: gomodel:663d668500002178/663d668500002574
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000274018
      - UniProtKB:Q57X56
      - MGI:MGI:1923750
      - UniProtKB:Q96PC2
      - UniProtKB:Q9UHH9
      - SGD:S000002424
      - dictyBase:DDB_G0278739
      - UniProtKB:Q92551
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC970.08
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0000828
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN004357288
      - UniProtKB:Q96PC2
      - MGI:MGI:1923750
      - CGD:CAL0000185409
      - TAIR:locus:2159203
      - SGD:S000002580
      - MGI:MGI:1916968
      - FB:FBgn0031267
      - SGD:S000002424
      - FB:FBgn0283680
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    term: GO:0032958
  causal_associations:
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002267
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000274018
      - UniProtKB:Q57X56
      - MGI:MGI:1923750
      - UniProtKB:Q96PC2
      - UniProtKB:Q9UHH9
      - SGD:S000002424
      - dictyBase:DDB_G0278739
      - UniProtKB:Q92551
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000274018
      - UniProtKB:Q57X56
      - MGI:MGI:1923750
      - UniProtKB:Q96PC2
      - UniProtKB:Q9UHH9
      - SGD:S000002424
      - dictyBase:DDB_G0278739
      - UniProtKB:Q92551
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002267
- id: gomodel:663d668500002178/663d668500002565
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000963723
      - SGD:S000002580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC607.04
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0008440
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN004357288
      - UniProtKB:Q96PC2
      - MGI:MGI:1923750
      - CGD:CAL0000185409
      - TAIR:locus:2159203
      - SGD:S000002580
      - MGI:MGI:1916968
      - FB:FBgn0031267
      - SGD:S000002424
      - FB:FBgn0283680
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    term: GO:0032958
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000963723
      - SGD:S000002580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002550
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000963723
      - SGD:S000002580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000963723
      - SGD:S000002580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002550
- id: gomodel:663d668500002178/663d668500002211
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:15249580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC19G12.14
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0052811
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:29975157
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000315
      reference: PMID:15249580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0046854
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:15249580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-09-08'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-09-08'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/66c7d41500001893
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:15249580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-09-08'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-09-08'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/66c7d41500001893
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:15249580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002532
- id: gomodel:663d668500002178/663d668500002550
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:10960485
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000374859
      - UniProtKB:Q580D3
      - UniProtKB:Q9H8X2
      - FB:FBgn0050295
      - RGD:1311271
      - TAIR:locus:2165437
      - PomBase:SPCC4B3.10c
      - SGD:S000002723
      - ZFIN:ZDB-GENE-050327-41
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC4B3.10c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0035299
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:10960485
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000374859
      - SGD:S000002723
      - TAIR:locus:2165437
      - PomBase:SPCC4B3.10c
      - CGD:CAL0000194997
      - FB:FBgn0050295
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    term: GO:0032958
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:10960485
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000374859
      - UniProtKB:Q580D3
      - UniProtKB:Q9H8X2
      - FB:FBgn0050295
      - RGD:1311271
      - TAIR:locus:2165437
      - PomBase:SPCC4B3.10c
      - SGD:S000002723
      - ZFIN:ZDB-GENE-050327-41
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002574
  - type: CausalAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:10960485
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000374859
      - UniProtKB:Q580D3
      - UniProtKB:Q9H8X2
      - FB:FBgn0050295
      - RGD:1311271
      - TAIR:locus:2165437
      - PomBase:SPCC4B3.10c
      - SGD:S000002723
      - ZFIN:ZDB-GENE-050327-41
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-24'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:663d668500002178/663d668500002574
- id: gomodel:663d668500002178/663d668500002205
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004296
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC577.06c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004430
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004296
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0046854
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:15249580
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-09-08'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-09-08'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/66c7d41500001893
- id: gomodel:663d668500002178/663d668500002281
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000269
      reference: PMID:1324908
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC1D4.08
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0003881
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0003881
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-05'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-05'
      provided_by:
      - http://www.pombase.org
    term: GO:0005789
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000269
      reference: PMID:1324908
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0006661
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-26'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/67b1629100003514
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-26'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/67b1629100003513
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000303
      reference: GO_REF:0000051
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-09-08'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-09-08'
      provided_by:
      - http://www.pombase.org
    molecule: gomodel:663d668500002178/66c7d41500001893
- id: gomodel:663d668500002178/663d668500002267
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:35536002
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC1672.06c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0052723
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:25254656
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-05-23'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-05-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0043647
molecules:
- id: gomodel:663d668500002178/66c7d41500001893
  term: CHEBI:16749
- id: gomodel:663d668500002178/67b1629100003514
  term: CHEBI:17268
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-14'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:663d668500002178/67c10cc400004789
  term: CHEBI:17268
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-14'
      provided_by:
      - http://www.pombase.org
    term: GO:0005576
- id: gomodel:663d668500002178/67b1629100003513
  term: CHEBI:58332
objects:
- id: CHEBI:16749
  label: 1-phosphatidyl-1D-myo-inositol
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: GO:0005366
  label: myo-inositol:proton symporter activity
  type: gocam:Object
- id: PomBase:SPAC20G8.03
  label: itr2 Spom
  type: gocam:Object
- id: GO:1904679
  label: myo-inositol import across plasma membrane
  type: gocam:Object
- id: GO:0005886
  label: plasma membrane
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0004430
  label: 1-phosphatidylinositol 4-kinase activity
  type: gocam:Object
- id: PomBase:SPBC577.06c
  label: stt4 Spom
  type: gocam:Object
- id: GO:0046854
  label: phosphatidylinositol phosphate biosynthetic process
  type: gocam:Object
- id: GO:0052811
  label: 1-phosphatidylinositol-3-phosphate 4-kinase activity
  type: gocam:Object
- id: PomBase:SPAC19G12.14
  label: its3 Spom
  type: gocam:Object
- id: GO:0052723
  label: inositol hexakisphosphate 1-kinase activity
  type: gocam:Object
- id: PomBase:SPCC1672.06c
  label: asp1 Spom
  type: gocam:Object
- id: GO:0043647
  label: inositol phosphate metabolic process
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0003881
  label: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
  type: gocam:Object
- id: PomBase:SPAC1D4.08
  label: pis1 Spom
  type: gocam:Object
- id: GO:0006661
  label: phosphatidylinositol biosynthetic process
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0043495
  label: protein-membrane adaptor activity
  type: gocam:Object
- id: PomBase:SPCC794.08
  label: efr3 Spom
  type: gocam:Object
- id: GO:0004435
  label: phosphatidylinositol-4,5-bisphosphate phospholipase C activity
  type: gocam:Object
- id: PomBase:SPAC22F8.11
  label: plc1 Spom
  type: gocam:Object
- id: GO:0032958
  label: inositol phosphate biosynthetic process
  type: gocam:Object
- id: PomBase:SPAC607.04
  label: arg82 Spom
  type: gocam:Object
- id: GO:0035299
  label: inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
  type: gocam:Object
- id: PomBase:SPCC4B3.10c
  label: ipk1 Spom
  type: gocam:Object
- id: GO:0008440
  label: inositol-1,4,5-trisphosphate 3-kinase activity
  type: gocam:Object
- id: GO:0000828
  label: inositol hexakisphosphate kinase activity
  type: gocam:Object
- id: PomBase:SPCC970.08
  label: kcs1 Spom
  type: gocam:Object
- id: CHEBI:58332
  label: CDP-diacylglycerol(2-)
  type: gocam:Object
- id: CHEBI:17268
  label: myo-inositol
  type: gocam:Object
- id: GO:0005789
  label: endoplasmic reticulum membrane
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0005576
  label: extracellular region
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-05-14'
  provided_by:
  - http://www.pombase.org
